Hydrochloric Acid → 3-Isobutylcyclobutylamine hydrochloride

HRID 1912102ノート

反応式

HRID 1912102 の反応式
[CH2:1]([CH:5]1[CH2:8][CH:7]([NH:9]C(=O)OC(C)(C)C)[CH2:6]1)[CH:2]([CH3:4])[CH3:3].[ClH:17]>O1CCOCC1>[ClH:17].[CH2:1]([CH:5]1[CH2:8][CH:7]([NH2:9])[CH2:6]1)[CH:2]([CH3:4])[CH3:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 71135570tert-Butyl (3-isobutylcyclobutyl)carbamate

生成物 1

HCID 866750563-Isobutylcyclobutylamine hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

tert-Butyl (3-isobutylcyclobutyl)carbamate (2.90 g) and dioxane (15 mL) were mixed. To the mixture was added a solution of 4 N hydrochloric acid in dioxane (15 mL) at 10° C. The mixture was stirred at RT overnight. The reaction mixture was concentrated in vacuo to give the title compound (1.97 g) as a crude product.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-1106295c842d4ad5bea490f4d03e1dd9
出典データセット
uspto-grants-2013_12
特許番号
US08604069B2

反応ノート

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