(S,E)-tert-butyl 4-(4-(methylsulfonyl)-2-aminobut-3-en-1-yl)benzylcarbamate → (S,E)-tert-butyl (5-amino-7-(methylsulfonyl)hept-6-en-1-yl)carbamate

HRID 1912369ノート

反応式

HRID 1912369 の反応式
C([NH:20][C@H:21](/[CH:34]=[CH:35]/[S:36]([CH3:39])(=[O:38])=[O:37])[CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30])(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.CS(/C=C/[C@@H](N)CC1C=CC(CNC(=O)OC(C)(C)C)=CC=1)(=O)=O>>[NH2:20][C@H:21](/[CH:34]=[CH:35]/[S:36]([CH3:39])(=[O:38])=[O:37])[CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30]

参加物

3

反応物 2

HCID 71562244(S,E)-tert-butyl 4-(4-(methylsulfonyl)-2-aminobut-3-en-1-yl)benzylcarbamateHCID 86681599(S,E)-tert-butyl (5-(trityl-amino)-7-(methylsulfonyl)hept-6-en-1-yl)carbamate

生成物 1

HCID 86681598(S,E)-tert-butyl (5-amino-7-(methylsulfonyl)hept-6-en-1-yl)carbamate

実験手順

This compound was prepared from trityl protected amine 73 in a synthetic procedure similar to that for compound 18. The purity was checked by LC-MS analysis and the amine was subjected to the next step without further purification.

後処理

  1. customThis compound was prepared from trityl
  2. customthe amine was subjected to the next step without further purification

出典と根拠

ORDレコード
ord-f5fe96721dad4745ad55a31604d810b3
出典データセット
uspto-grants-2013_12
特許番号
US08609610B2

反応ノート

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