1,4-Dioxane hydrochloride → 3,3-Difluoro-1,6-diazaspiro[3,4]octane
反応式
C(OC([N:8]1[CH2:17][CH2:16][C:10]2([NH:13][CH2:12][C:11]2([F:15])[F:14])[CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1.Cl.CO>C(OCC)(=O)C>[F:14][C:11]1([F:15])[C:10]2([CH2:16][CH2:17][NH:8][CH2:9]2)[NH:13][CH2:12]1参加物
5
実験手順
To an optically-active compound of 3,3-difluoro-1,6-diazaspiro[3,4]octane-6-carboxylic acid tert-butyl ester (211 mg) were added 4M hydrochloric acid-1,4-dioxane (2.1 ml) and 2M hydrochloric acid-methanol (2.1 ml), and the mixture was stirred at room temperature for 45 minutes. To the reaction mixture was added ethyl acetate, and the mixture was filtered to give the titled compound (163 mg).
後処理
- filtrationthe mixture was filtered
出典と根拠
- ORDレコード
- ord-942dc82627814c0095355308d8c14c86
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08609647B2
反応ノート
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