[CH2:1]([O:8][CH:9]([C:14]([O:16]C)=O)[C:10](OC)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[Na+].Cl.[CH:22]([NH2:24])=[NH:23].Cl>CO>[CH2:1]([O:8][C:9]1[C:14]([OH:16])=[N:23][CH:22]=[N:24][C:10]=1[OH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Dimethyl 2-(benzyloxy)malonate (16.1 g, 0.0675 mol) was dissolved in MeOH (27 ml), NaOMe (42.59 ml of a 30% solution in MeOH, 3.5 eq) was added and the mixture cooled to 0 C. Formamidine hydrochloride (5.68 g, 1.05 eq) was added and the mixture stirred at 0° C. for 30 minutes and then at reflux for 2 hours. After cooling to 0° C. concentrated HCl (21 ml) was added and the solid was collected by filtration (washing with cold water 3×20 ml) to give 15.14 g of the title compound.
読み込み中…
