4-(4-Nitro-2-(trifluoromethyl)phenylethynyl)pyridine → 4-(2-Pyridin-4-yl-ethyl)-3-(trifluoromethyl)aniline

関与物質

反応手順

In 20 mL of ethanol, 1.3 g (4.45 mmol) of 4-(4-nitro-2-(trifluoromethyl)phenylethynyl)pyridine was dissolved and stirred on 100 mg of 10% palladium carbon overnight at room temperature in a hydrogen atmosphere. The catalyst was removed by filtration and the filtrate was concentrated and the residue was purified by a silica gel column (n-hexane:ethyl acetate=1:2) to obtain 1.0 g (85%) of a target product as a pale yellow oil.

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