(3,5-Dimethoxyphenyl)acetic acid → 2-(3,5-dimethoxyphenyl)-N-[3-(3-fluorophenyl)pyrazolo[1,5-a]pyrimidin-2-yl]acetamide

HRID 1912942

反応式

HRID 1912942 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C:12]([OH:14])=O)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[F:15][C:16]1[CH:17]=[C:18]([C:22]2[C:23]([NH2:31])=[N:24][N:25]3[CH:30]=[CH:29][CH:28]=[N:27][C:26]=23)[CH:19]=[CH:20][CH:21]=1>>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([CH2:11][C:12]([NH:31][C:23]2[C:22]([C:18]3[CH:19]=[CH:20][CH:21]=[C:16]([F:15])[CH:17]=3)=[C:26]3[N:27]=[CH:28][CH:29]=[CH:30][N:25]3[N:24]=2)=[O:14])[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

参加物

3

反応物 2

HCID 138316(3,5-Dimethoxyphenyl)acetic acidHCID 68751731HCID 68751731、化合物

生成物 1

HCID 687489772-(3,5-dimethoxyphenyl)-N-[3-(3-fluorophenyl)pyrazolo[1,5-a]pyrimidin-2-yl]acetamide

実験手順

3,5-Dimethoxyphenylacetic acid and the product from Example 128A were processed as using the method analogous to that described in example 104 to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 10.40-10.51 (bs, 1H), 9.11 (dd, J=7.0, 1.8 Hz, 1H), 8.65 (dd, J=4.1, 1.7 Hz, 1H), 7.59 (ddd, J=11.2, 2.6, 1.6 Hz, 1H), 7.52 (d, J=7.9 Hz, 1H), 7.26-7.34 (m, 1H), 7.16 (dd, J=7.0, 4.1 Hz, 1H), 7.02-7.09 (m, 1H), 6.46-6.54 (m, 2H), 6.38-6.43 (m, 1H), 3.67-3.77 (bs, 6H), 3.59-3.62 (bs, 2H); MS (ESI) m/z 407 (M+H)+. Anal. calculated for C22H19FN4O3: C, 65.02; H, 4.71; N, 13.79. Found C, 64.80; H, 4.54; N, 13.77.

出典と根拠

ORDレコード
ord-50475ca0ee864b4a8bfe11e70b89a70c
出典データセット
uspto-grants-2013_12
特許番号
US08609669B2

関連ノート

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