3,3-Dimethyl-1-butenylboronic acid → HCID 68752051、化合物

HRID 1912948ノート

反応式

HRID 1912948 の反応式
[CH3:1][C:2]([CH3:9])([CH3:8])[CH:3]=[CH:4]B(O)O.[CH3:10][C:11]([CH3:32])([CH3:31])[CH2:12][C:13]([NH:15][C:16]1[C:24](C2C=NC=CC=2)=[C:19]2[N:20]=[CH:21][CH:22]=[CH:23][N:18]2[N:17]=1)=[O:14]>>[CH3:1][C:2]([CH3:9])([CH3:8])/[CH:3]=[CH:4]/[C:24]1[C:16]([NH:15][C:13](=[O:14])[CH2:12][C:11]([CH3:31])([CH3:10])[CH3:32])=[N:17][N:18]2[CH:23]=[CH:22][CH:21]=[N:20][C:19]=12

参加物

3

反応物 2

HCID 27632983,3-Dimethyl-1-butenylboronic acidHCID 687511603,3-dimethyl-N-[3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-2-yl]butanamide

生成物 1

HCID 68752051HCID 68752051、化合物

実験手順

3,3-Dimethyl-1-butenylboronic acid (Aalenchem) and the product from Example 110B were processed using the method analogous to that described in Example 110C to provide the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 10.03-10.05 (bs, 1H), 9.00 (dd, J=6.9, 1.7 Hz, 1H), 8.57 (dd, J=4.1, 1.7 Hz, 1H), 7.03 (dd, J=6.9, 4.1 Hz, 1H), 6.75 (d, J=16.3 Hz, 1H), 6.23 (d, J=16.3 Hz, 1H), 2.26 (s, 2H), 1.09 (s, 9H), 1.07 (s, 9H); MS (ESI) m/z 315 (M+H)+.

出典と根拠

ORDレコード
ord-791790233c89419b98e11d91535a1acc
出典データセット
uspto-grants-2013_12
特許番号
US08609669B2

反応ノート

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