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2-Cyclohexylideneacetic acid → N-(3-tert-butylpyrazolo[1,5-a]pyrimidin-2-yl)-2-cyclohexylideneacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Cyclohexylideneacetic acid | HCID 96206 | — |
| 反応物 | 3-Tert-butylpyrazolo[1,5-a]pyrimidin-2-amine | HCID 68755471 | — |
| 生成物 | N-(3-tert-butylpyrazolo[1,5-a]pyrimidin-2-yl)-2-cyclohexylideneacetamide | HCID 68753367 | — |
反応手順
The product from Example 105B and 2-cyclohexylideneacetic acid were processed using the method analogous to that described in Example 137 to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.44 (s, 9H), 1.50-1.63 (m, 6H), 2.15-2.18 (m, 2H), 2.80-2.82 (m, 2H), 5.80 (br s, 1H), 6.98 (dd, J=6.8, 4.1 Hz, 1H), 8.48 (dd, J=4.1, 2.0 Hz, 1H), 8.91 (dd, J=7.1, 1.7 Hz, 1H), 9.58 (br s, 1H); MS (DCI) m/z 313 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08609669B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-ba2a614f52be4f9cae11d9c54690e7d7 |
| 出典メモ | uspto-grants-2013_12 |