Cyclohexylacetyl chloride → HCID 68750170、化合物
反応式
[C:1]([C:5]1[C:6]([NH2:15])=[N:7][N:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[CH:16]1([CH2:22][C:23](Cl)=[O:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[C:1]([C:5]1[C:6]([NH:15][C:23](=[O:24])[CH2:22][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[N:7][N:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2]参加物
3
実験手順
The product from Example 178A and cyclohexylacetyl chloride were processed using the method analogous to that described in Example 105C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.91-1.03 (m, 2H), 1.11-1.30 (m, 3H), 1.43 (s, 9H), 1.59-1.80 (m, 6H), 2.16-2.18 (m, 2H), 2.29 (d, J=1.0 Hz, 1H), 8.38 (d, J=2.0 Hz, 1H), 8.75 (s, 1H), 9.58 (br s, 1H); MS (DCI) m/z 329 (M+H)+.
出典と根拠
- ORDレコード
- ord-0cb67c7a81574d0b9effa715f9167099
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08609669B2
反応ノート
読み込み中…