Ammonia → HCID 66584856、化合物
反応式
Cl[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH:11]2[CH2:16][CH2:15][S:14][CH2:13][CH2:12]2)[CH:3]=1.[NH3:17]>CO>[S:14]1[CH2:15][CH2:16][CH:11]([C:4]2[CH:3]=[C:2]([NH2:17])[N:7]3[N:8]=[CH:9][CH:10]=[C:6]3[N:5]=2)[CH2:12][CH2:13]1参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of 7-chloro-5-(tetrahydro-2H-thiopyran-4-yl)pyrazolo[1,5-a]pyrimidine (Int-1c, 1.52 g, 6.0 mmol) in a solution of ammonia in MeOH (7 N, 20 mL) was heated in sealed vessel at 80° C. for 5 h. The reaction mixture was cooled down and concentrated. The residue was dried in high vacuum and used for the next step without further purification. LC/MS RT=0.92 Min (5 min method). Mass calculated for, M+H 235.09, observed 235.09.
後処理
- temperatureThe reaction mixture was cooled down
- concentrationconcentrated
- customThe residue was dried in high vacuum
- customused for the next step without further purification
- customLC/MS RT=0.92 Min (5 min method)
出典と根拠
- ORDレコード
- ord-3842b0faf4ee4e919ff1ee8b0818101b
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08609675B2
反応ノート
読み込み中…