HCID 18340695、化合物 → Ethyl 4-(2-tert-butoxy-2-oxoethyl)cyclohexanecarboxylate

HRID 1913212ノート

反応式

HRID 1913212 の反応式
[C:1]([O:5][C:6](=[O:19])[CH:7]=[C:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2]>CCOC(C)=O>[C:1]([O:5][C:6](=[O:19])[CH2:7][CH:8]1[CH2:9][CH2:10][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:12][CH2:13]1)([CH3:3])([CH3:4])[CH3:2]

参加物

3

反応物 1

HCID 18340695HCID 18340695、化合物

生成物 1

HCID 66613615Ethyl 4-(2-tert-butoxy-2-oxoethyl)cyclohexanecarboxylate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a 250 mL round-bottom flask was charged ethyl 4-(2-tert-butoxy-2-oxoethylidene)cyclohexanecarboxylate (Int-4a, 5.38 g, 19.90 mmol) followed by EtOAc (100 mL). The flask was flushed with argon and then 5% palladium on carbon was added. The flask was sealed and degassed under vacuum. H2 (g) was added in a balloon and the reaction was allowed to stir 18 hours under hydrogen atmosphere. After 18 hours, the reaction mixture was filtered through celite. The solvent was removed in vacuo and the resulting oil was taken on without further purification.

後処理

  1. customThe flask was flushed with argon
  2. addition5% palladium on carbon was added
  3. customThe flask was sealed
  4. customdegassed under vacuum
  5. additionH2 (g) was added in a balloon
  6. waitAfter 18 hours
  7. filtrationthe reaction mixture was filtered through celite
  8. customThe solvent was removed in vacuo
  9. customthe resulting oil was taken on without further purification

出典と根拠

ORDレコード
ord-6fa096afaeb1418ea822e43253b338f9
出典データセット
uspto-grants-2013_12
特許番号
US08609675B2

反応ノート

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