Hydrochloric Acid → 2-(4-(Ethoxycarbonyl)cyclohexyl)acetic acid

HRID 1913213ノート

反応式

HRID 1913213 の反応式
C([O:5][C:6](=[O:19])[CH2:7][CH:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)(C)(C)C.Cl>O1CCOCC1>[CH2:17]([O:16][C:14]([CH:11]1[CH2:12][CH2:13][CH:8]([CH2:7][C:6]([OH:19])=[O:5])[CH2:9][CH2:10]1)=[O:15])[CH3:18]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 66613615Ethyl 4-(2-tert-butoxy-2-oxoethyl)cyclohexanecarboxylate

生成物 1

HCID 158961922-(4-(Ethoxycarbonyl)cyclohexyl)acetic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a 100 mL round-bottom flask was charged ethyl 4-(2-tert-butoxy-2-oxoethyl)cyclohexanecarboxylate (Int-4b, 2.00 g, 7.40 mmol) and 4N HCl in 1,4-dioxane. The resulting solution was stirred at room temperature for 2 hours. At this point the solvent was removed in vacuo and the resulting residue was diluted with DCM and washed with H2O. The organic layer was dried over Na2SO4 and reduced in vacuo. The resulting residue was taken on without further purification.

後処理

  1. customAt this point the solvent was removed in vacuo
  2. additionthe resulting residue was diluted with DCM
  3. washwashed with H2O
  4. dry with materialThe organic layer was dried over Na2SO4
  5. customThe resulting residue was taken on without further purification

出典と根拠

ORDレコード
ord-11b5d88ef7354042b7aaa5721929ff84
出典データセット
uspto-grants-2013_12
特許番号
US08609675B2

反応ノート

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