HCID 66879199、化合物 → HCID 178468818、化合物

HRID 1913215ノート

反応式

HRID 1913215 の反応式
C(O[C:4](=[O:20])[CH2:5][C:6](=O)[CH2:7][CH:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)C.[NH2:21][C:22]1[CH:26]=[CH:25][NH:24][N:23]=1>CCO>[OH:20][C:4]1[N:23]2[N:24]=[CH:25][CH:26]=[C:22]2[N:21]=[C:6]([CH2:7][CH:8]2[CH2:9][CH2:10][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:12][CH2:13]2)[CH:5]=1

参加物

4

反応物 2

HCID 66879199HCID 66879199、化合物HCID 178418806HCID 178418806、化合物

生成物 1

HCID 178468818HCID 178468818、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
100 °C

実験手順

To a 50 mL round-bottom flask containing ethyl 4-(4-ethoxy-2,4-dioxobutyl)cyclohexanecarboxylate (Int-4e, 2.33 g, 8.19 mmol) was added 3-amino-1H-pyrazole (681 mg, 8.19 mmol). The flask was heated via heat gun to ensure mixing of the oils, and then the reaction was shaken at 100° C. for 18 hours. After 18 hours, the resulting solid was taken up in EtOH and then the solvent was removed in vacuo to dry product. The product was then pumped dry on high vacuum overnight to further dry the product. The compound was taken on without further purification.

後処理

  1. temperatureThe flask was heated
  2. temperaturevia heat gun
  3. additionto ensure mixing of the oils
  4. waitAfter 18 hours
  5. customthe solvent was removed in vacuo to dry product
  6. customThe product was then pumped dry on high vacuum overnight
  7. customto further dry the product
  8. customThe compound was taken on without further purification

出典と根拠

ORDレコード
ord-86c4127d0e6a40f7922627b45bcfc556
出典データセット
uspto-grants-2013_12
特許番号
US08609675B2

反応ノート

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