Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate → HCID 178515484、化合物

HRID 1913227ノート

反応式

HRID 1913227 の反応式
O=[C:2]([CH:9]1[CH2:18][CH2:17][C:12]2([O:16][CH2:15][CH2:14][O:13]2)[CH2:11][CH2:10]1)[CH2:3][C:4]([O:6]CC)=O.[NH2:19][C:20]1[CH:24]=[CH:23][NH:22][N:21]=1>CCO>[O:13]1[C:12]2([CH2:11][CH2:10][CH:9]([C:2]3[CH:3]=[C:4]([OH:6])[N:21]4[N:22]=[CH:23][CH:24]=[C:20]4[N:19]=3)[CH2:18][CH2:17]2)[O:16][CH2:15][CH2:14]1

参加物

4

反応物 2

HCID 66733231Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoateHCID 178418806HCID 178418806、化合物

生成物 1

HCID 178515484HCID 178515484、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
100 °C

実験手順

To a 20 mL scintillation vial containing ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate (Int-5d, 11.7 mmol, 3.00 g) was added 3-amino-1H-pyrazole (11.7 mmol, 973 mg). The mixture was mixed and heated neat at 100° C. for 3 hours. The resulting off-white solid was taken up in EtOH (100 mL) and reduced in vacuo to remove water formed during cyclization. This solid was taken forward without further purification.

後処理

  1. additionThe mixture was mixed
  2. customto remove water
  3. customformed during cyclization
  4. customThis solid was taken forward without further purification

出典と根拠

ORDレコード
ord-0aa7901b78364218a7d604840122b8ef
出典データセット
uspto-grants-2013_12
特許番号
US08609675B2

反応ノート

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