Hydrochloric Acid → Ethyl 1-methyl-4-oxocyclohexanecarboxylate

HRID 1913235

反応式

HRID 1913235 の反応式
[CH3:1][C:2]1([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:11][CH2:10][C:5]2(OCC[O:6]2)[CH2:4][CH2:3]1.CCO.O.Cl>O1CCOCC1>[CH3:1][C:2]1([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:3][CH2:4][C:5](=[O:6])[CH2:10][CH2:11]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 962WaterHCID 19004805Ethyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate

生成物 1

HCID 21911973Ethyl 1-methyl-4-oxocyclohexanecarboxylate

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

In a 50 mL round-bottom flask was mixed with ethyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate (Int-6a, 1.99 g, 8.72 mmol), EtOH (10 mL), H2O (5 mL), and 4N HCl in 1,4-dioxane (5 mL). The resulting solution was stirred at room temperature for 64 hours. At this time, the solvent was removed in vacuo and the residue was taken up in DCM. The suspension was washed with saturated NaHCO3(aq) and the organic layer was dried over Na2SO4. The resulting product was taken on without further purification. Yield=1.00 g.

後処理

  1. customAt this time, the solvent was removed in vacuo
  2. washThe suspension was washed with saturated NaHCO3(aq)
  3. dry with materialthe organic layer was dried over Na2SO4
  4. customThe resulting product was taken on without further purification

出典と根拠

ORDレコード
ord-d027fab779754691829fdfd85cf0c6a8
出典データセット
uspto-grants-2013_12
特許番号
US08609675B2

関連ノート

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