2-Methoxybenzoyl chloride → HCID 67365319、化合物

HRID 1914102ノート

反応式

HRID 1914102 の反応式
Cl.[OH:2][C:3]1[CH:4]=[C:5]([C:11]2[C:12]([CH3:24])([CH3:23])[C:13](=[O:22])[N:14]([CH:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[N:15]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH3:25][O:26][C:27]1[CH:35]=[CH:34][CH:33]=[CH:32][C:28]=1[C:29](Cl)=[O:30]>>[OH:2][C:3]1[CH:4]=[C:5]([C:11]2[C:12]([CH3:24])([CH3:23])[C:13](=[O:22])[N:14]([CH:16]3[CH2:21][CH2:20][N:19]([C:29]([C:28]4[CH:32]=[CH:33][CH:34]=[CH:35][C:27]=4[O:26][CH3:25])=[O:30])[CH2:18][CH2:17]3)[N:15]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

参加物

3

反応物 2

HCID 889692-Methoxybenzoyl chlorideHCID 67366287HCID 67366287、化合物

生成物 1

HCID 67365319HCID 67365319、化合物

実験手順

The title compound is prepared analogously as described for GP1 using 5-(3-hydroxy-4-methoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B11*HCl) and 2-methoxybenzoyl chloride as starting compounds. The crude product is purified by crystallization from EA and diethyl ether to yield 5-(3-hydroxy-4-methoxyphenyl)-2-{1-[(2-methoxyphenyl)carbonyl]piperidin-4-yl}-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one as the product.

後処理

  1. customThe title compound is prepared analogously
  2. customThe crude product is purified by crystallization from EA and diethyl ether

出典と根拠

ORDレコード
ord-f8b77865aca14e8aafc93c50358560c0
出典データセット
uspto-grants-2013_12
特許番号
US08609848B2

反応ノート

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