Quinoline-7-carboxylic acid → 5-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-[1-(quinolin-7-ylcarbonyl)piperidin-4-yl]-2,4-dihydro-3H-pyrazol-3-one

HRID 1914116

反応式

HRID 1914116 の反応式
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].[N:26]1[C:35]2[C:30](=[CH:31][CH:32]=[C:33]([C:36](O)=[O:37])[CH:34]=2)[CH:29]=[CH:28][CH:27]=1>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][N:20]([C:36]([C:33]4[CH:34]=[C:35]5[C:30]([CH:29]=[CH:28][CH:27]=[N:26]5)=[CH:31][CH:32]=4)=[O:37])[CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

参加物

3

反応物 2

HCID 599475Quinoline-7-carboxylic acidHCID 666164065-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride2 回

生成物 1

HCID 462052965-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-[1-(quinolin-7-ylcarbonyl)piperidin-4-yl]-2,4-dihydro-3H-pyrazol-3-one

実験手順

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and quinoline-7-carboxylic acid as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from DCM and diethyl ether to yield the title compound.

後処理

  1. customThe title compound is prepared analogously
  2. customThe crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from DCM and diethyl ether

出典と根拠

ORDレコード
ord-3c4356c8bfdb45309a196313db63ac7d
出典データセット
uspto-grants-2013_12
特許番号
US08609848B2

関連ノート

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