2-Methyl-1-naphthalenecarboxylic acid → 5-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-{1-[(2-methylnaphthalen-1-yl)carbonyl]piperidin-4-yl}-2,4-dihydro-3H-pyrazol-3-one

HRID 1914183

反応式

HRID 1914183 の反応式
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].[CH3:26][C:27]1[CH:36]=[CH:35][C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:28]=1[C:37](O)=[O:38]>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][N:20]([C:37]([C:28]4[C:29]5[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=5)[CH:35]=[CH:36][C:27]=4[CH3:26])=[O:38])[CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

参加物

3

反応物 2

HCID 740912-Methyl-1-naphthalenecarboxylic acidHCID 666164065-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride2 回

生成物 1

HCID 673651875-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-{1-[(2-methylnaphthalen-1-yl)carbonyl]piperidin-4-yl}-2,4-dihydro-3H-pyrazol-3-one

実験手順

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 2-methylnaphthalene-1-carboxylic acid as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from diethyl ether to yield the title compound.

後処理

  1. customThe title compound is prepared analogously
  2. customThe crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from diethyl ether

出典と根拠

ORDレコード
ord-4448662b48d940cc96e77f878cfa80f9
出典データセット
uspto-grants-2013_12
特許番号
US08609848B2

関連ノート

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