Potassium Hydroxide → 2-Bromo-5-phenylthiophene-3-carboxylic acid

HRID 1914541ノート

反応式

HRID 1914541 の反応式
[OH-].[K+].C([O:5][C:6]([C:8]1[CH:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[S:10][C:9]=1[Br:19])=[O:7])C>O>[Br:19][C:9]1[S:10][C:11]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[CH:12][C:8]=1[C:6]([OH:7])=[O:5]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 581102722-Bromo-5-phenyl-thiophene-3-carboxylic acid ethyl ester

生成物 1

HCID 581103102-Bromo-5-phenylthiophene-3-carboxylic acid収率 87%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Potassium hydroxide (0.65 g, 11.6 mmol) in water (2 mL) was added to a solution of 2-bromo-5-phenyl-thiophene-3-carboxylic acid ethyl ester (3.9 mmol) in IMS (6 mL). The reaction was stirred for 1 hour and then partitioned between diethyl ether and water. The aqueous layer was acidified to pH 7 with 1 N hydrochloric acid and further extracted with diethyl ether. The organic solution was dried over magnesium sulfate, filtered and the solvent evaporated to give the title compound (0.96 g, 87%). LCMS m/z 281.97 [M−H]− R.T.=3.64 min. (Analytical Method 5).

後処理

  1. custompartitioned between diethyl ether and water
  2. extractionfurther extracted with diethyl ether
  3. dry with materialThe organic solution was dried over magnesium sulfate
  4. filtrationfiltered
  5. customthe solvent evaporated

出典と根拠

ORDレコード
ord-c662300dae1e4066917c421fb4d88319
出典データセット
uspto-grants-2013_12
特許番号
US08614209B2

反応ノート

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