Methylamine → 7-chloro-N-methyl-6-phenylimidazo[1,2-a]pyrimidin-5-amine

HRID 1915537ノート

反応式

HRID 1915537 の反応式
Cl[C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([Cl:11])[C:3]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[CH3:18][NH2:19]>CO>[Cl:11][C:4]1[C:3]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:2]([NH:19][CH3:18])[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[N:5]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 862136335,7-Dichloro-6-phenylimidazo[1,2-a]pyrimidine

生成物 1

HCID 866306607-chloro-N-methyl-6-phenylimidazo[1,2-a]pyrimidin-5-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

850 mg 5,7-dichloro-6-phenylimidazo[1,2-a]pyrimidine (prepared as described for example 1) is dissolved in 18 ml of a 8M Solution of MeNH2 in methanol and stirred at room temperature for 1.5 h. The product precipitates upon dilution with water and cooling to 0° C. The solid material is collected by filtration and washed twice with water to yield the desired material.

後処理

  1. customThe product precipitates upon dilution with water
  2. temperaturecooling to 0° C
  3. filtrationThe solid material is collected by filtration
  4. washwashed twice with water

出典と根拠

ORDレコード
ord-e4215f3267884a53a907346bd50189ef
出典データセット
uspto-grants-2013_12
特許番号
US08614218B2

反応ノート

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