Sodium Methoxide → 5-Chloro-7-methoxy-6-phenylpyrazolo[1,5-a]pyrimidine

HRID 1915561ノート

反応式

HRID 1915561 の反応式
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6](Cl)[N:5]2[N:15]=[CH:16][CH:17]=[C:4]2[N:3]=1.[CH3:18][O-:19].[Na+]>CO.ClCCl.O>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6]([O:19][CH3:18])[N:5]2[N:15]=[CH:16][CH:17]=[C:4]2[N:3]=1

参加物

6

反応物 2

HCID 10942334Sodium MethoxideHCID 594278075,7-Dichloro-6-phenylpyrazolo[1,5-a]pyrimidine

生成物 1

HCID 866306725-Chloro-7-methoxy-6-phenylpyrazolo[1,5-a]pyrimidine

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 962Water溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

1.00 g 5,7-dichloro-6-phenylpyrazolo[1,5-a]pyrimidine (prepared as described under example 19) are dissolved in 20 ml methanol and 20 ml dichlormethane. 1.2 g sodium methylate is added at 0° C. and stirred at room temperature for 2 h. The solution is diluted with water and dichloromethane. The organic phase separated and the water phase is extracted with dichloromethane. The combined organic layers are dried over Na2SO4 and the solvent is evaporated. The crude product is used without further purification.

後処理

  1. customThe organic phase separated
  2. extractionthe water phase is extracted with dichloromethane
  3. dry with materialThe combined organic layers are dried over Na2SO4
  4. customthe solvent is evaporated
  5. customThe crude product is used without further purification

出典と根拠

ORDレコード
ord-168c418ed45f4dfebef77fe8961274c6
出典データセット
uspto-grants-2013_12
特許番号
US08614218B2

反応ノート

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