Triethylamine → HCID 68407751、化合物

HRID 1916022ノート

反応式

HRID 1916022 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](Cl)=[O:6].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2([F:25])[CH2:23][CH:22]2[NH2:24])=[CH:17][CH:16]=1.C(N(CC)CC)C>ClCCl>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([C@@:21]2([F:25])[CH2:23][C@H:22]2[NH:24][C:5](=[O:6])[C:4]2[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=2[C:2]([F:13])([F:12])[F:1])=[CH:19][CH:20]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 675612-(Trifluoromethyl)benzoyl chlorideHCID 44398212HCID 44398212、化合物

生成物 1

HCID 68407751HCID 68407751、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 2-trifluoromethylbenzoyl chloride (0.10 g; 0.54 mmol) in dichloromethane (2 ml) added dropwise to a stirred solution of the amine from example P5 (compound Z1.004; 2-(4-chlorophenyl)-2-fluoro-cyclopropylamine; 0.100 g; 0.54 mmol) and triethylamine (0.15 ml; 1.08 m) in dichloromethane (3 ml). Stirred for 1 hr at room temperature then allowed to stand for 18 hr. The white precipitate was filtered off, washed with 2M HCl, saturated NaHCO3 and water and air dried giving the pure cis isomer. 0.065 g (34%).

後処理

  1. waitto stand for 18 hr
  2. filtrationThe white precipitate was filtered off
  3. washwashed with 2M HCl, saturated NaHCO3 and water and air
  4. customdried
  5. customgiving the pure cis isomer

出典と根拠

ORDレコード
ord-f70d5a8add9d40ffa81ceb8eb089972e
出典データセット
uspto-grants-2013_12
特許番号
US08618023B2

反応ノート

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