HCID 136124671、化合物 → HCID 136124682、化合物
反応式
[CH3:1][S:2]([O:5][C@H:6]([C:8]1[NH:9][C:10](=[O:23])[C:11]2[CH:16]=[N:15][N:14]([CH:17]3[CH2:22][CH2:21]OC[CH2:18]3)[C:12]=2[N:13]=1)[CH3:7])(=[O:4])=[O:3].O[C@H](C1NC(=O)C2C=NN(C3CCOCC3)C=2N=1)C>>[CH3:1][S:2]([O:5][C@H:6]([C:8]1[NH:9][C:10](=[O:23])[C:11]2[CH:16]=[N:15][N:14]([CH:17]3[CH2:22][CH2:21][CH2:18]3)[C:12]=2[N:13]=1)[CH3:7])(=[O:3])=[O:4]参加物
3
実験手順
Compound C18 was prepared according to the general procedure for the synthesis of C5 in Example 1, except that C17 was used in place of C4, and the chromatographic purification was carried out with 0.5% to 1% MeOH in chloroform, rather than 0% to 5% MeOH in dichloromethane, to provide C18 as a solid. Yield: 6.0 g, 19.2 mmol, 79%. LCMS m/z 311.4 (M−1). 1H NMR (400 MHz, CDCl3) 1.85 (d, J=6.6 Hz, 3H), 1.93 (m, 2H), 2.46 (m, 2H), 2.78 (m, 2H), 3.23 (s, 3H), 5.29 (m, 1H), 5.69 (q, J=6.6 Hz, 1H), 8.08 (s, 1H), 11.65 (br s, 1H). 13C NMR (100 MHz, CDCl3) δ 14.93, 20.39, 29.84, 38.75, 51.07, 74.91, 104.98, 134.71, 151.07, 155.61, 159.27.
後処理
- customCompound C18 was prepared
- customthe chromatographic purification
- customto provide C18 as a solid