化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → Methyl 2-hydroxy-5-iodo-3-methylbenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-Hydroxy-5-iodo-3-methylbenzoic acid | HCID 15908685 | — |
| 生成物 | Methyl 2-hydroxy-5-iodo-3-methylbenzoate | HCID 14172484 | — |
反応手順
A solution of 2.0 g (7.19 mmol) 2-hydroxy-5-iodo-3-methyl-benzoic acid in 5.0 mL thionyl chloride (69.0 mmol) is stirred for 20 min at 80° C. Thionyl chloride is eliminated i.vac. and the residue is combined with 20 mL MeOH and stirred for 20 min at RT. The product is precipitated out of the reaction. MeOH is eliminated i.vac. down to 5 mL and the residue is suction filtered. The product is further reacted without any more purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08618132B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-14bc186e27e24c299a0c3914c5a30543 |
| 出典メモ | uspto-grants-2013_12 |