5-nitro-1-(2-pyrrolidin-1-yl-ethyl)-1H-indazole → 1-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-5-ylamine

HRID 1916665ノート

反応式

HRID 1916665 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH2:14][N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1)[N:8]=[CH:7]2)([O-])=O>[Ni].CCOC(C)=O>[N:15]1([CH2:14][CH2:13][N:9]2[C:10]3[C:6](=[CH:5][C:4]([NH2:1])=[CH:12][CH:11]=3)[CH:7]=[N:8]2)[CH2:19][CH2:18][CH2:17][CH2:16]1

参加物

4

反応物 1

HCID 220365795-nitro-1-(2-pyrrolidin-1-yl-ethyl)-1H-indazole

生成物 1

HCID 113107771-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-5-ylamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8857Ethyl Acetate溶媒

実験手順

0.50 g Raney nickel are added to a solution of 3.50 g (13.4 mmol) 5-nitro-1-(2-pyrrolidin-1-yl-ethyl)-1H-indazole in 50 mL EtOAc and the reaction mixture is stirred for 20 h at RT at 1.4 bar H2. After filtration the solvent is eliminated i.vac. The product is further reacted without any more purification.

後処理

  1. filtrationAfter filtration the solvent
  2. customThe product is further reacted without any more purification

出典と根拠

ORDレコード
ord-bf897fffa7a9484e967c5bb41ad61533
出典データセット
uspto-grants-2013_12
特許番号
US08618132B2

反応ノート

読み込み中…