Stannous Chloride → 2-Bromo-5-(4-chloro-phenyl)-pyridin-3-ylamine

HRID 1916674ノート

反応式

HRID 1916674 の反応式
[Br:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:4][N:3]=1.[Sn](Cl)Cl.C([O-])(O)=O.[Na+]>CCOC(C)=O>[Br:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([C:11]2[CH:12]=[CH:13][C:14]([Cl:17])=[CH:15][CH:16]=2)=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 24479Stannous ChlorideHCID 516892Sodium BicarbonateHCID 859696992-Bromo-5-(4-chlorophenyl)-3-nitropyridine

生成物 1

HCID 859697042-Bromo-5-(4-chloro-phenyl)-pyridin-3-ylamine

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 5.60 g (17.9 mmol) 2-bromo-5-(4-chloro-phenyl)-3-nitro-pyridine, 20.3 g (90.0 mmol) tin(II)-chloride and 18.9 g (225 mmol) NaHCO3 in 300 mL EtOAc is refluxed for 30 h. After filtration the solvent is eliminated i.vac. The residue is triturated with DCM and after filtration the filter residue is dried in the air.

後処理

  1. filtrationAfter filtration the solvent
  2. customThe residue is triturated with DCM
  3. filtrationafter filtration the filter residue
  4. customis dried in the air

出典と根拠

ORDレコード
ord-b841da7b84814a379a6b0c6a8e1534bf
出典データセット
uspto-grants-2013_12
特許番号
US08618132B2

反応ノート

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