Water → HCID 67363953、化合物

HRID 1916692ノート

反応式

HRID 1916692 の反応式
I[C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][OH:9])=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]=[CH:21][C:22]([C:25]#[CH:26])=[N:23][CH:24]=2)=[CH:15][CH:14]=1.O.CCOC(C)=O>N1CCCCC1.[Cu]I>[Cl:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:20]=[CH:21][C:22]([C:25]#[C:26][C:2]3[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][OH:9])=[CH:4][CH:3]=3)=[N:23][CH:24]=2)=[CH:17][CH:18]=1

参加物

7

反応物 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 35132082-(4-Iodophenoxy)ethanolHCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridine

生成物 1

HCID 67363953HCID 67363953、化合物

試薬・触媒・溶媒 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 8082Piperidine溶媒

実験手順

Under an argon atmosphere 253 mg (0.22 mmol) tetrakis-triphenylphosphane-palladium and 42 mg (0.22 mmol) CuI are added to a solution of 2.9 g (11 mmol) 2-(4-iodo-phenoxy)-ethanol and 2.35 g (11 mmol) 5-(4-chloro-phenyl)-2-ethynyl-pyridine in 50 mL piperidine and the reaction mixture is stirred for 30 min at RT. The solvent is eliminated i.vac., the residue is combined with water and stirred with EtOAc. The product precipitated is suction filtered and dried.

後処理

  1. customThe product precipitated
  2. filtrationfiltered
  3. customdried

出典と根拠

ORDレコード
ord-45fe597784e64715ae44abf0a7de67b6
出典データセット
uspto-grants-2013_12
特許番号
US08618132B2

反応ノート

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