Acetyl chloride → N-(2-(4-methoxyphenylthio)ethyl)acetamide

HRID 1917066ノート

反応式

HRID 1917066 の反応式
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH2:11][CH2:12][NH2:13])=[CH:6][CH:5]=1.[C:14](Cl)(=[O:16])[CH3:15].C(N(CC)CC)C>C(Cl)Cl>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH2:11][CH2:12][NH:13][C:14](=[O:16])[CH3:15])=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 122619332-(4-Methoxyphenylthio)ethanamine hydrochloride

生成物 1

HCID 49865266N-(2-(4-methoxyphenylthio)ethyl)acetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of compound 1-HCl (0.44 g) in CH2Cl2 (15 mL) cooled to ˜0° C. was added acetyl chloride (1.0 mL) and triethylamine (1.0 mL). The reaction mixture was stirred for 1 hour at 0° C. and washed with 1N HCl, sat. NaHCO3. The solvents were removed by evaporation under reduced pressure to give product 10 as solid (pure by TLC and NMR). Yield: 0.5 g.

後処理

  1. washwashed with 1N HCl, sat. NaHCO3
  2. customThe solvents were removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-9e9f51fbe6684a45be1b76f13041ff09
出典データセット
uspto-grants-2013_12
特許番号
US08618282B2

反応ノート

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