関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Malic Acid | HCID 525 | — |
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Sunitinib | HCID 5329102 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | Sunitinib Malate | HCID 6456015 | — |
反応手順
1 g of sunitinib base was dissolved in 3 ml of N-methyl pyrrolidone, at RT 0.336 g of Malic acid added (as a solid): the solution was heated to 40° C. than 15 ml of toluene was added and precipitation was observed. The suspension was kept at 40° C. for 1 hour than cooled to 0° C., filtered and washed with toluene. Dried at 60° C. under vacuum for 16 h.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08618309B2 |
|---|
| 出典データセット | uspto-grants-2013_12 |
|---|
| ORD ID | ord-37ec831ba5254c55a2c895c3466e369c |
|---|
| 出典メモ | uspto-grants-2013_12 |
|---|
