化工社化工社 化学情報印刷レポート · 研究参考用
Malic Acid → Sunitinib Malate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Malic Acid | HCID 525 | — |
| 反応物 | 1-Propanol | HCID 1031 | — |
| 反応物 | Sunitinib | HCID 5329102 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | Sunitinib Malate | HCID 6456015 | — |
反応手順
2 g of sunitinib base were suspended in 6 ml of NMP under stirring at RT. 0.673 g of Malic acid were added to the mixture and the temperature was set at 40° C. 40 ml n-propanol were dropped in 30 minutes, the suspension was cooled to 0° C., filtered and washed with 10 ml n-propanol. Dried at 70° C. under vacuum for 16 h.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08618309B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-3999f844e5a14739bf783d924cfdb0e2 |
| 出典メモ | uspto-grants-2013_12 |