関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 反応物 | Tri-tert-butylphosphine tetrafluoroborate | HCID 2734635 | — |
| 反応物 | 3-Chloro-4-methoxybenzeneboronic acid | HCID 3247522 | — |
| 反応物 | 3-Bromo-4-(trifluoromethyl)benzoic acid | HCID 22337570 | — |
| 触媒 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 3'-Chloro-4'-methoxy-6-trifluoromethyl-biphenyl-3-carboxylic Acid | HCID 67170103 | — |
反応手順
3-Bromo-4-trifluoromethyl-benzoic acid (0.484 g, 1.80 mmol), 3-chloro-4-methoxy-phenylboronic acid (0.503 g, 2.70 mmol), tri-tert-butylphosphonium tetrafluoroborate (0.313 g, 1.08 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.494 g, 0.54 mmol) and potassium fluoride (0.345 g, 5.93 mmol) were weighed into a flask and dioxane (10 ml) was added under argon, and the mixture was stirred for 24 h at 50° C. The mixture was filtered over celite and evaporated to dryness. The residue was purified by preparative RP HPLC (water/ACN gradient) to yield the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08618304B2 |
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| 出典データセット | uspto-grants-2013_12 |
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| ORD ID | ord-ed36e323c5e94d36ab0f8f5e9845ba20 |
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| 出典メモ | uspto-grants-2013_12 |
|---|
