6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → 1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2-oxopyrrolidine-3-carboxylic acid
反応式
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[F:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][C:20]=1[C:21]([F:24])([F:23])[F:22])[NH2:17]>C(O)C>[F:13][C:14]1[CH:15]=[C:16]([N:17]2[CH2:6][CH2:7][CH:5]([C:8]([OH:9])=[O:10])[C:4]2=[O:11])[CH:18]=[CH:19][C:20]=1[C:21]([F:23])([F:24])[F:22]参加物
4
実験手順
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 3-fluoro-4-(trifluoromethyl)aniline (0.806 g; 4.36 mmol) in ethanol (3 mL). 1-(3-fluoro-4-(trifluoromethyl)phenyl)-2-oxopyrrolidine-3-carboxylic acid 0.147 g (35%) was obtained as a solid.
後処理
- customThis compound was prepared
出典と根拠
- ORDレコード
- ord-28b865c8c9a445349ea21fc4a88aba82
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08618138B2
反応ノート
読み込み中…