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6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → 1-(1,3-Dihydroisobenzofuran-5-yl)-2-oxopyrrolidine-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| 反応物 | 1,3-Dihydro-2-benzofuran-5-amine | HCID 12445339 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(1,3-Dihydroisobenzofuran-5-yl)-2-oxopyrrolidine-3-carboxylic acid | HCID 66832166 | 84% |
反応手順
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 1,3-dihydroisobenzofuran-5-amine (0.608 g; 4.36 mmol) in ethanol (3 mL). 1-(1,3-dihydroisobenzofuran-5-yl)-2-oxopyrrolidine-3-carboxylic acid 0.300 g (84%) was obtained as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08618138B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-96996e79c05247b094d34051687de30c |
| 出典メモ | uspto-grants-2013_12 |