1,4-Dioxane hydrochloride → 3-(4-(Azetidin-3-yl)phenylamino)-5-bromo-1-methylpyrazin-2(1H)-one Hydrochloride
反応式
[Br:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]3[CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16]3)=[CH:11][CH:10]=2)[C:5](=[O:26])[N:4]([CH3:27])[CH:3]=1.[ClH:28].O1CCOCC1>CO>[ClH:28].[NH:17]1[CH2:18][CH:15]([C:12]2[CH:11]=[CH:10][C:9]([NH:8][C:6]3[C:5](=[O:26])[N:4]([CH3:27])[CH:3]=[C:2]([Br:1])[N:7]=3)=[CH:14][CH:13]=2)[CH2:16]1参加物
4
実験手順
A mixture of 298b (690 mg, 1.6 mmol) and HCl/1,4-dioxane (8M, 8 mL) in methanol (30 mL) was stirred at room temperature overnight. The mixture was evaporated in vacuo and the residue was purified on reverse phase Combi-flash to give 298c (100 mg, 17%). MS: [M+H]+ 335.
後処理
- customThe mixture was evaporated in vacuo
- customthe residue was purified on reverse phase Combi-flash
出典と根拠
- ORDレコード
- ord-dd84b521ecd34ecda81fe15746dd0636
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08618107B2
反応ノート
読み込み中…