Morpholine → 5-Chloro-2-methyl-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidine

HRID 1919359ノート

反応式

HRID 1919359 の反応式
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][C:9]([CH3:11])=[N:8][C:6]=2[N:7]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>CO.CCOC(C)=O.O>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH3:11])=[N:8][C:6]=2[N:7]=1

参加物

6

反応物 2

HCID 8083MorpholineHCID 582349525,7-Dichloro-2-methylthiazolo[4,5-d]pyrimidine

生成物 1

HCID 582349545-Chloro-2-methyl-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidine収率 90%

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 5,7-dichloro-2-methyl-thiazolo[4,5-d]pyrimidine (92 mg, 0.42 mmol) in MeOH (3 mL) was added morpholine (81 μL, 0.93 mmol) and the mixture stirred at RT for 1 h. The reaction mixture was diluted with EtOAc and H2O. The organic layer was isolated, washed with brine, then dried (MgSO4) and concentrated in vacuo. The resultant residue was purified by column chromatography to give the title compound as a cream solid (102 mg, 90%).

後処理

  1. customThe organic layer was isolated
  2. washwashed with brine
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customThe resultant residue was purified by column chromatography

出典と根拠

ORDレコード
ord-eaea9edf5a8c483c9cb144b3e1addc39
出典データセット
uspto-grants-2012_05
特許番号
US08168633B2

反応ノート

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