Ethanol hydrochloride → 3-[4-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione

HRID 1919765ノート

反応式

HRID 1919765 の反応式
Cl.C(O)C.[F:5][C:6]([F:41])([F:40])[C:7]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:31](=[O:32])[C:30]([CH3:34])([CH3:33])[N:29]([CH3:35])[C:28]2=[O:36])=[C:18]([CH2:37][CH2:38][CH3:39])[CH:17]=1)([O:12]COC)[C:8]([F:11])([F:10])[F:9]>>[F:41][C:6]([F:5])([F:40])[C:7]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:31](=[O:32])[C:30]([CH3:33])([CH3:34])[N:29]([CH3:35])[C:28]2=[O:36])=[C:18]([CH2:37][CH2:38][CH3:39])[CH:17]=1)([OH:12])[C:8]([F:11])([F:10])[F:9]

参加物

3

反応物 2

HCID 21887872Ethanol hydrochlorideHCID 249910743-[4-[4-[1,1,1,3,3,3-Hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione

生成物 1

HCID 249910753-[4-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione収率 82%

実験手順

Hydrochloric acid-ethanol (2 mol/L, 2 mL) was added to 3-[4-[4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione (55.7 mg, 0.11 mmol), followed by stirring at room temperature for one hour. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by silica gel preparative thin-layer chromatography (hexane:ethyl acetate=2:1) to obtain 41.8 mg of the title compound (yield: 82%) as a colorless crystalline powder.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe resulting residue was purified by silica gel preparative thin-layer chromatography (hexane:ethyl acetate=2:1)

出典と根拠

ORDレコード
ord-a48bdc306b234139afa9579015d3ee0b
出典データセット
uspto-grants-2012_05
特許番号
US08168666B2

反応ノート

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