4-(2,2,2-Trifluoroethoxy)benzonitrile → 1-(4-(2,2,2-Trifluoroethoxy)phenyl)ethan-1-amine

HRID 1919825ノート

反応式

HRID 1919825 の反応式
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH:11](N)[CH3:12])=[CH:7][CH:6]=1.F[C:17](F)(F)COC1C=CC(C#N)=CC=1>>[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]([NH2:10])[CH3:17])=[CH:7][CH:6]=1

参加物

3

反応物 2

HCID 109545944-(2,2,2-Trifluoroethoxy)benzonitrileHCID 586291003-Pyridinemethanamine, alpha-methyl-6-(2,2,2-trifluoroethoxy)-

生成物 1

HCID 167823401-(4-(2,2,2-Trifluoroethoxy)phenyl)ethan-1-amine

実験手順

The title compound was synthesised according to the procedure described for the synthesis of 1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethanamine, step B, starting from 4-(2,2,2-trifluoroethoxy)benzonitrile. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.28-7.34 (m, 2 H) 6.94-7.00 (m, 2 H) 4.70 (q, J=8.78 Hz, 2 H) 3.95 (q, J=6.53 Hz, 1 H) 1.21 (d, J=6.78 Hz, 3 H). MS (ESI) m/z: 220 [M+H]

出典と根拠

ORDレコード
ord-1c0fd56d89774018bff4bd7dc3b4c189
出典データセット
uspto-grants-2012_05
特許番号
US08168668B2

反応ノート

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