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HRID 1919893作成日：2026年10月27日
Benzoic Acid → Methyl 4-{2-[benzoyl(2,4-dimethoxybenzyl)amino]-3-[(4-chlorophenyl)amino]-3-oxopropyl}benzoate
https://huagongshe.com/reaction/1919893
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzoic Acid | HCID 243 | — |
| 反応物 | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| 反応物 | 4-Chlorophenyl isocyanide | HCID 74670 | — |
| 反応物 | 2,4-Dimethoxybenzylamine | HCID 597250 | — |
| 反応物 | Methyl 4-(2-oxoethyl)benzoate | HCID 13844675 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 4-{2-[benzoyl(2,4-dimethoxybenzyl)amino]-3-[(4-chlorophenyl)amino]-3-oxopropyl}benzoate | HCID 57611867 | — |
反応手順
Methyl 4-formylmethylbenzoate (56.3 mg, 0.316 mmol, 4-chlorophenyl isocyanide (43.5 mg, 0.316 mmol), 1-(2,4-dimethoxyphenyl)methanamine (56.9 μL, 0.379 mmol) and benzoic acid (38.6 mg, 0.316 mmol) were dissolved in 100 μL of trifluoroethanol and heated at 50° C. for 2 hours. The reaction mixture was diluted with 2 mL of methanol and purified by reversed phase HPLC to afford the desired product. MS cal'd 587.2 (MH+), exp 587.2 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08168658B2 |
|---|
| 出典データセット | uspto-grants-2012_05 |
|---|
| ORD ID | ord-ac5957fb35274ce48a08668e57be7c1a |
|---|
| 出典メモ | uspto-grants-2012_05 |
|---|
