[4-Methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester → [2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4'-(1-hydroxy-1-methyl-ethyl)-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester

HRID 1920023

反応式

HRID 1920023 の反応式
[CH2:1]([O:8][C:9](=[O:25])[N:10]([CH2:13][C:14]1[CH:19]=[C:18]([C:20]([OH:23])([CH3:22])[CH3:21])[CH:17]=[CH:16][C:15]=1Br)[CH2:11][CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:26]([O:28][C:29](=[O:48])[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[C:33](B2OC(C)(C)C(C)(C)O2)[CH:32]=1)[CH3:27]>>[CH2:26]([O:28][C:29](=[O:48])[CH2:30][C:31]1[CH:32]=[C:33]([C:15]2[CH:16]=[CH:17][C:18]([C:20]([OH:23])([CH3:22])[CH3:21])=[CH:19][C:14]=2[CH2:13][N:10]([C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:25])[CH2:11][CH3:12])[C:34]([O:37][CH3:38])=[CH:35][CH:36]=1)[CH3:27]

参加物

3

反応物 2

HCID 58120060[4-Methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl esterHCID 58149231[2-Bromo-5-(1-hydroxy-1-methyl-ethyl)-benzyl]-ethyl-carbamic acid benzyl ester

生成物 1

HCID 58149060[2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4'-(1-hydroxy-1-methyl-ethyl)-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester

実験手順

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: [2-bromo-5-(1-hydroxy-1-methyl-ethyl)-benzyl]-ethyl-carbamic acid benzyl ester and [4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-227bfc5c2a204ce9844dda2cd1fcfd00
出典データセット
uspto-grants-2012_05
特許番号
US08168678B2

関連ノート

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