化工社化工社 化学情報印刷レポート · 研究参考用
Bromine → 2-(6-amino-8-bromo-9H-purin-9-yl)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 2-(6-Aminopurin-9-yl)ethanol | HCID 242652 | — |
| 溶媒 | sodium;acetic acid;acetate | HCID 178476574 | — |
| 生成物 | 2-(6-amino-8-bromo-9H-purin-9-yl)ethanol | HCID 44572469 | 43% |
反応手順
To a solution of 10 g 2-(6-amino-purin-9-yl)ethanol in 200 ml 0.5M AcONa/AcOH buffer pH 4 were added 4 ml of Br2. The resulting mixture was stirred at room temperature for 8 hours. The precipitated product was isolated, washed with water and crystallized from ethanol to give 6.13 g (43%) of the desired compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08173609B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-7c2c581a412e4451ae310470494ed016 |
| 出典メモ | uspto-grants-2012_05 |