1,1'-sulphonylbis-1H-imidazole → 4-Amino-5-ethoxy-1,2,3-benzoxathiazine 2,2-dioxide

HRID 1920713ノート

反応式

HRID 1920713 の反応式
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:5]=1[C:11](=[NH:13])[NH2:12])[CH3:2].[S:14](N1C=CN=C1)(N1C=CN=C1)(=[O:16])=[O:15]>O>[NH2:13][C:11]1[C:5]2[C:4]([O:3][CH2:1][CH3:2])=[CH:9][CH:8]=[CH:7][C:6]=2[O:10][S:14](=[O:16])(=[O:15])[N:12]=1

参加物

4

反応物 2

HCID 816091,1'-sulphonylbis-1H-imidazoleHCID 1360739132-Ethoxy-6-hydroxybenzenecarboximidamide

生成物 1

HCID 462386994-Amino-5-ethoxy-1,2,3-benzoxathiazine 2,2-dioxide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

0.25 g (1.39 mmol) of 2-ethoxy-6-hydroxybenzenecarboximidamide is stirred without solvent with 0.65 g (3.28 mmol) of 1,1′-sulphonyldiimidazole at 130° C. for 18 hours. Cooling is followed by stirring the mixture with water and removing with dichloromethane. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. This gives 0.2 g of a pale yellow, crystalline material.

後処理

  1. temperatureCooling
  2. customremoving with dichloromethane
  3. dry with materialThe organic phase is dried over magnesium sulphate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-db444358b5064ccea948f1c2d8203590
出典データセット
uspto-grants-2012_05
特許番号
US08173641B2

反応ノート

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