HCID 57733375、化合物 → HCID 57733330、化合物

HRID 1920750ノート

反応式

HRID 1920750 の反応式
[CH2:1]([O:3][C:4](=[O:16])[CH:5]=[C:6]1[CH2:11][CH2:10][N:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:8][CH2:7]1)[CH3:2].[H][H]>C(O)C>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][CH:6]1[CH2:7][CH2:8][N:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:10][CH2:11]1)[CH3:2]

参加物

4

反応物 2

HCID 57733375HCID 57733375、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 57733330HCID 57733330、化合物収率 78%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of (1-tert-butyl-piperidin-4-ylidene)-acetic acid ethyl ester (5.1 g, 22.7 mmol) in ethanol (50 mL) 10% Pd/C (0.6 g) was added and the mixture was stirred under the hydrogen atmosphere (42 psi) at ambient temperature for 14 hours. The catalyst was removed by filtration, and the filtrate was concentrated to give the title (4.03 g, yield 78%), which was used in the next step directly.

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customto give the title (4.03 g, yield 78%), which

出典と根拠

ORDレコード
ord-3fd4387adce24d1f9ff5c2e7e14fbab6
出典データセット
uspto-grants-2012_05
特許番号
US08173639B2

反応ノート

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