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N-(4-methyl-3-nitrophenyl)cyclopropanecarboxamide → N-(3-amino-4-methylphenyl)cyclopropanecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(4-methyl-3-nitrophenyl)cyclopropanecarboxamide | HCID 4104437 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-(3-amino-4-methylphenyl)cyclopropanecarboxamide | HCID 24693537 | 94.8% |
反応手順
N-(4-Methyl-3-nitrophenyl)cyclopropanecarboxamide (409 mg) was hydrogenated over 10% Pd/C (50% wet, 80 mg) at atmospheric pressure of hydrogen in MeOH (20 mL) for 5 hr. The catalyst was removed by filtration through Celite® pad and the filtrate was evaporated in vacuo to give N-(3-amino-4-methylphenyl)cyclopropanecarboxamide (335 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08173684B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-1148f2f8c34e49a9a37dc682729e6a91 |
| 出典メモ | uspto-grants-2012_05 |