Morpholine → HCID 59558570、化合物

HRID 1921321ノート

反応式

HRID 1921321 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10]Br)=[C:6]([CH:9]=1)[C:7]#[N:8].[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.C(N(CC)CC)C>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:6]([CH:9]=1)[C:7]#[N:8]

参加物

5

反応物 3

HCID 8083MorpholineHCID 8471TriethylamineHCID 442031405-Bromo-2-(bromomethyl)benzonitrile

生成物 1

HCID 59558570HCID 59558570、化合物収率 74.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-Bromo-2-bromomethylbenzonitrile (2.50 g, 9.1 mmol) is added portionwise to a stirred solution of morpholine (828 μL, 9.5 mmol) and triethylamine (1.27 mL, 9.1 mmol) in methanol (2 mL). After 4 hr, the solvent is removed and the residue is suspended in water that is made basic with sodium hydroxide and then extracted with ethyl acetate. The extract is dried, filtered, and concentrated to give 5-bromo-2-(morpholin-4-yl)methylbenzonitrile (1.90 g, 74%) as a cream solid.

後処理

  1. customthe solvent is removed
  2. extractionextracted with ethyl acetate
  3. customThe extract is dried
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-97029078feef4f5a96ce09f9e59535e8
出典データセット
uspto-grants-2012_05
特許番号
US08173682B2

反応ノート

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