関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dabco | HCID 9237 | — |
| 反応物 | 4-((1-Methyl-4-piperidinyl)methoxy)benzenamine | HCID 11564798 | — |
| 反応物 | 5,8-Dibromoimidazo[1,2-a]pyrazine | HCID 53485949 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | (5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-[4-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-amine | HCID 59023106 | — |
反応手順
To a solution of 5,8-dibromo-imidazo[1,2-a]pyrazine (0.100 g, 0.36 mmol) in isopropanol (5 mL) are added 1,4-diazabicyclo[2,2,2]octane (DABCO) (0.036 mL, 0.36 mmol) and 4-(1-methyl-piperidin-4-ylmethoxy)-phenylamine (79.6 mg, 0.36 mmol). The reaction mixture is stirred at 90° C. overnight. The solvent is evaporated and the residue chromatographed on silica gel column eluting with 97:3 followed by 94:6 and 90:10 DCM:MeOH. The title compound is obtained as a solid (20 mg, 13%). LCMS: Rt 2.30 min (94%), m/z (APCI) 417.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08173656B2 |
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| 出典データセット | uspto-grants-2012_05 |
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| ORD ID | ord-e3b8de7b6dbb45e09e7c471d0220aa6e |
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| 出典メモ | uspto-grants-2012_05 |
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