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Diisopropylethylamine → (5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-[3-fluoro-4-(4-methyl-piperazin-1-yl)-phenyl]-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline | HCID 2783055 | — |
| 反応物 | 5,8-Dibromoimidazo[1,2-a]pyrazine | HCID 53485949 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | (5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-[3-fluoro-4-(4-methyl-piperazin-1-yl)-phenyl]-amine | HCID 59023046 | 5% |
反応手順
Following the general procedure for amine displacement using 5,8-dibromoimidazo[1,2-a]pyrazine (0.50 g, 1.81 mmol), 3-fluoro-4-(4-methyl-piperazin-1-yl)-phenylamine (0.45 g, 2.17 mmol) and DIPEA (0.47 mL, 2.72 mmol) in iPrOH (5 mL). The crude material is purified by silica gel column chromatography eluting with 90:10 DCM:MeOH to give the title compound (35 mg, 5%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08173656B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-d6a0cb2a2c1247a7888d18d625289a5f |
| 出典メモ | uspto-grants-2012_05 |