Hydrochloric Acid → 4-(4-amino-6-methoxynaphthalen-2-yl)-N,N-dimethylpyrimidin-2-amine hydrochloride

HRID 1921974ノート

反応式

HRID 1921974 の反応式
[CH3:1][N:2]([CH3:29])[C:3]1[N:8]=[C:7]([C:9]2[CH:10]=[C:11]([NH:21]C(=O)OC(C)(C)C)[C:12]3[C:17]([CH:18]=2)=[CH:16][CH:15]=[C:14]([O:19][CH3:20])[CH:13]=3)[CH:6]=[CH:5][N:4]=1.[ClH:30].C(OCC)C>ClCCl.O1CCOCC1>[ClH:30].[NH2:21][C:11]1[C:12]2[C:17](=[CH:16][CH:15]=[C:14]([O:19][CH3:20])[CH:13]=2)[CH:18]=[C:9]([C:7]2[CH:6]=[CH:5][N:4]=[C:3]([N:2]([CH3:1])[CH3:29])[N:8]=2)[CH:10]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 68288489HCID 68288489、化合物

生成物 1

HCID 673061954-(4-amino-6-methoxynaphthalen-2-yl)-N,N-dimethylpyrimidin-2-amine hydrochloride

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of tert-butyl (3-(2-(dimethylamino)pyrimidin-4-yl)-7-methoxynaphthalen-1-yl)carbamate (140) (261 mg, 0.66 mmol) in dichloromethane (5 ml) was added 4 M hydrochloric acid in dioxane (2 ml). The mixture was stirred at room temperature for 24 hours. Diethylether (100 ml) was added and the solid filtered off and dried under vacuum to give 4-(4-amino-6-methoxynaphthalen-2-yl)-N,N-dimethylpyrimidin-2-amine (141) as a yellow solid.

後処理

  1. filtrationthe solid filtered off
  2. customdried under vacuum

出典と根拠

ORDレコード
ord-9395e3688eb64c218241136d63b20b39
出典データセット
uspto-grants-2012_05
特許番号
US08173808B2

反応ノート

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