関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrogen Peroxide | HCID 784 | — |
| 反応物 | 5-Ethyl-2-pyridineethanol | HCID 78894 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-(5-Ethyl-1-oxidopyridin-1-ium-2-yl)ethanol | HCID 66823399 | 81.8% |
反応手順
To a solution of 100 g (0.655 mol) 2-(5-ethyl-pyridin-2-yl)-ethanol in 500 mL acetic acid was added 118 g (1.049 mol) 30% hydrogen peroxide at 25-30° C. Reaction mixture was refluxed at 100° C. (tlc) for 14 hr. After completion of the reaction acetic acid was removed under vacuum, and the residual mass was poured in excess water and made alkaline by 10% Na2CO3 solution. Product was extracted with ethyl acetate and after concentrating ethyl acetate in vacuo, 89.58 g (81%) crystalline product was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08173816B2 |
|---|
| 出典データセット | uspto-grants-2012_05 |
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| ORD ID | ord-f90525ffda694b53b374bdf258fe6a2e |
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| 出典メモ | uspto-grants-2012_05 |
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