3-Amino-4-fluorophenol → N-(2-fluoro-5-hydroxyphenyl)-3-oxo-2-(4-pyrazol-1-ylbenzyl)butyramide

反応式

C(S[C:6](=[O:23])[CH:7]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH:22]=[CH:21][CH:20]=[N:19]2)=[CH:14][CH:13]=1)[C:8](=[O:10])[CH3:9])(C)(C)C.[NH2:24][C:25]1[CH:26]=[C:27]([OH:32])[CH:28]=[CH:29][C:30]=1[F:31]>>[F:31][C:30]1[CH:29]=[CH:28][C:27]([OH:32])=[CH:26][C:25]=1[NH:24][C:6](=[O:23])[CH:7]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([N:18]2[CH:22]=[CH:21][CH:20]=[N:19]2)=[CH:16][CH:17]=1)[C:8](=[O:10])[CH3:9]

参加物

反応物 2

HCID 135191803-Amino-4-fluorophenol

HCID 866423723-oxo-2-(4-pyrazol-1-ylbenzyl)thiobutyric acid S-tert-butyl ester

生成物 1

HCID 86642373N-(2-fluoro-5-hydroxyphenyl)-3-oxo-2-(4-pyrazol-1-ylbenzyl)butyramide

実験手順

The title compound was prepared by the method of Preparation 11b using 3-oxo-2-(4-pyrazol-1-ylbenzyl)thiobutyric acid S-tert-butyl ester and 3-amino-4-fluorophenol.

出典と根拠

ORDレコード: ord-a599f213fd3343be8b3220424b64302b
出典データセット: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08173812B2

反応ノート

読み込み中…