Hydrogen Peroxide → HCID 59536621、化合物

HRID 1922174ノート

反応式

HRID 1922174 の反応式
[OH:1]O.[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8](B(O)O)=[C:7]([CH3:14])[N:6]=1.O>ClCCl>[CH3:3][O:4][C:5]1[N:6]=[C:7]([CH3:14])[C:8]([OH:1])=[CH:9][CH:10]=1

参加物

5

反応物 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 27630842-Methyl-6-methoxypyridine-3-boronic acid

生成物 1

HCID 59536621HCID 59536621、化合物収率 62.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Add hydrogen peroxide (7.69 mL, 89.8 mmol) to a stirred mixture of 2-methoxy-6-methyl-5-pyridylboronic acid (5.0 g, 30 mmol) in dichloromethane (100 mL) kept under nitrogen at room temperature. Stir overnight at ambient temperature, add water and extract the mixture with dichloromethane. Combine the organic phases, dry (MgSO4), filter and concentrate to afford 2.6 g (62%) of the title compound. MS (m/z)=140 [M+1]

後処理

  1. customkept under nitrogen at room temperature
  2. extractionextract the mixture with dichloromethane
  3. dry with materialdry (MgSO4)
  4. filtrationfilter
  5. concentrationconcentrate

出典と根拠

ORDレコード
ord-15719b56bbb1479dae037ccbf7d0d6db
出典データセット
uspto-grants-2012_05
特許番号
US08173821B2

反応ノート

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